The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. All of the Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 5 NFL picks now. The latest Week 5 NFL spreads list the Buccaneers (-10) as the only other double-digit favorite as they take on the Falcons with first place in the NFC South on the line.

In their last seven games as double-digit favorites, Buffalo is 5-1-1 against the spread, so betting Kenny Pickett and the Steelers could be one of the riskier NFL picks and NFL bets. Buffalo is the largest favorite on the board according to the latest Week 5 NFL odds from Caesars Sportsbook, spotting the Steelers 14 points at home.

The NFL has already seen 26 underdogs win outright through the first four weeks of the 2022 season, and going against the favorites has been a profitable NFL betting strategy whether you're playing the spread or the money line.

Points spread for nfl oct 1 game